1. Introduction
This study investigated the variables associated with dropout of survivors of acute lymphoblastic leukemia in a trial investigating the effect of vitamin D and calcium supplementation and nutritional counseling on bone mineral density (BMD). · In healthy children, bone mineral density (BMD) continues to increase until early in the third decade of life, 2 but children with ALL can develop reduced BMD because of the disease, its treatment, nutritional deficiencies, and/or physical inactivity. Glucocorticoids decrease bone formation by promoting apoptosis of osteoblasts and osteocytes, increasing bone resorption Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia Cheryl L. Cox, PhD, 1 Liang Zhu, PhD, 2 Sue C. Kaste, DO, 1,3 Kumar Srivastava, PhD, 1 Linda Barnes, BSN, CRA, 1 Paul C. Nathan, MD, MSc, 4 Robert J. Wells, MD, 5 and Kirsten K. Ness, PhD 1Author: Cheryl L. Cox, Liang Zhu, Sue C. Kaste, Sue C. Kaste, Kumar Srivastava, Linda Barnes, Paul C. Nathan
Publication types
As survival rates of children with acute lymphoblastic leukemia (ALL) have substantially improved, the understanding of both short- and long-term side effects of ALL treatment has become increasingly important. 1 Severe osteogenic side-effects of ALL treatment include osteonecrosis 2 – 11 and bone mineral density (BMD) loss, 12 – 17 which often occur during and shortly after Background: The objective of this study was to evaluate bone mineral density (BMD) after completion of treatment for childhood acute lymphoblastic leukemia (ALL). Methods: In this cross-sectional study, survivors of ALL aged ± who completed their treatment at least one year earlier were enrolled Background: The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm 2), and health-related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation-based intervention, beginning after diagnosis and continuing through the end of treatment, to positively modify Author: Cheryl L. Cox, Liang Zhu, Sue C. Kaste, Sue C. Kaste, Kumar Srivastava, Linda Barnes, Paul C. Nathan
Introduction
As survival rates of children with acute lymphoblastic leukemia (ALL) have substantially improved, the understanding of both short- and long-term side effects of ALL treatment has become increasingly important. 1 Severe osteogenic side-effects of ALL treatment include osteonecrosis 2 – 11 and bone mineral density (BMD) loss, 12 – 17 which often occur during and shortly after Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia Cheryl L. Cox, PhD, 1 Liang Zhu, PhD, 2 Sue C. Kaste, DO, 1,3 Kumar Srivastava, PhD, 1 Linda Barnes, BSN, CRA, 1 Paul C. Nathan, MD, MSc, 4 Robert J. Wells, MD, 5 and Kirsten K. Ness, PhD 1Author: Cheryl L. Cox, Liang Zhu, Sue C. Kaste, Sue C. Kaste, Kumar Srivastava, Linda Barnes, Paul C. Nathan This study investigated the variables associated with dropout of survivors of acute lymphoblastic leukemia in a trial investigating the effect of vitamin D and calcium supplementation and nutritional counseling on bone mineral density (BMD).
Associated Data
· In healthy children, bone mineral density (BMD) continues to increase until early in the third decade of life, 2 but children with ALL can develop reduced BMD because of the disease, its treatment, nutritional deficiencies, and/or physical inactivity. Glucocorticoids decrease bone formation by promoting apoptosis of osteoblasts and osteocytes, increasing bone resorption Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia Cheryl L. Cox, PhD, 1 Liang Zhu, PhD, 2 Sue C. Kaste, DO, 1,3 Kumar Srivastava, PhD, 1 Linda Barnes, BSN, CRA, 1 Paul C. Nathan, MD, MSc, 4 Robert J. Wells, MD, 5 and Kirsten K. Ness, PhD 1Author: Cheryl L. Cox, Liang Zhu, Sue C. Kaste, Sue C. Kaste, Kumar Srivastava, Linda Barnes, Paul C. Nathan Background: The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm 2), and health-related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation-based intervention, beginning after diagnosis and continuing through the end of treatment, to positively modify Author: Cheryl L. Cox, Liang Zhu, Sue C. Kaste, Sue C. Kaste, Kumar Srivastava, Linda Barnes, Paul C. Nathan
MeSH terms
· There are prominent hypodensities in distal femoral metaphyses and proximal tibial metaphyses with some area of sclerosis. Some lytic lesions exist in the left femoral neck. Otherwise the bone density is reduced (Figure 4). The patient was sent for bone marrow aspiration. The final diagnosis was acute myeloid leukemia (AML) As survival rates of children with acute lymphoblastic leukemia (ALL) have substantially improved, the understanding of both short- and long-term side effects of ALL treatment has become increasingly important. 1 Severe osteogenic side-effects of ALL treatment include osteonecrosis 2 – 11 and bone mineral density (BMD) loss, 12 – 17 which often occur during and shortly after Abstract Although reduced bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL) is well documented, the degree of demineralization and relation to age are not well described. This is a retrospective chart analysis of 58 patients consecutively treated for ALL without relapse, cranial irradiation, or transplantation
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